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Corticosteroids are useful in early disease as temporary adjunctive therapy while waiting for DMARDs to exert their antiinflammatory effects. As part of the clinical trials, we investigated the effects of a DMARD on the clinical and functional state of individuals with irritable bowel syndrome. METHODS: We randomly assigned 10 patients with functional gastrointestinal disorders to receive DMARD in combination with a standard therapy of oral furosemide plus corticosteroids. A 6-week open-label phase was used to evaluate the effectiveness of DMARD in the therapy of irritable bowel syndrome. RESULTS: During the open-label phase, mean (SD) decrease in bowel frequency at baseline of the first 3 months was 7 (3.6) ± 1.8 per month (M-MD) after treatment with DMARD. There were significant decreases within all subgroups (P≤0.05), including age (11.2 +/- 0.9 months, n = 6; age range 14-29 years, n = 9), body mass index (25.2 +/- 0.5 kg/m2, n = 10; M < 0.10, n = 4), and duration of gastrointestinal symptoms (10 years, n = 11; 10-29 year, M = 8.6, 3.9; 30-54, 11.0, 6.3) at the end of 6 weeks. Mean reduction in bowel frequency was significantly higher in the DMARD-treated group (14.5% ± 3.9) than in the placebo group after 6 weeks (mean, 8.0% ± 1.9) (P = 0.0039; Student's t -test). CONCLUSIONS: Oral furosemide plus DMARD is effective in suppressing postprandial hyperactivity in patients with irritable bowel syndrome. TRIAL REGISTRATION: Trial registration ClinicalTrials.gov NCT00748679. Similar articles: